| Multi-Assistance Center at Morgans WonderlandSan Antonio | Form 990 | $11,024,910FY2024 |
| Make-a-Wish Foundation of the Texas Gulf Coast and Louisiana IncStafford | Form 990 | $10,936,356FY2025 |
| Easter Seals-Central Texas IncAustin | Form 990 | $10,785,669FY2025 |
| Martin Luther King Jr Family ClinicDallas | Form 990 | $10,566,967FY2024 |
| South Texas Emergency Care Foundation IncHarlingen | Form 990 | $10,493,562FY2025 |
| South Texas Rural Health Services IncCotulla | Form 990 | $10,112,168FY2025 |
| Southeast Texas Regional Advisory CouncilHouston | Form 990 | $9,715,004FY2024 |
| Womens and Mens Health Services of the Coastal Bend IncCorpus Christi | Form 990 | $9,608,553FY2025 |
| Ellis County Coalition for Health OptionsWaxahachie | Form 990 | $9,496,111FY2024 |
| Sheldon Community Volunteer Fire & Rescue IncHouston | Form 990 | $9,436,101FY2025 |
| Ronald McDonald House Charities Greater Houston IncHouston | Form 990 | $9,202,612FY2024 |
| Ascension Depaul ServicesSan Antonio | Form 990 | $9,099,315FY2025 |
| Health Opportunities for the People of East Texas IncCenter | Form 990 | $8,974,670FY2025 |
| Clinical Data Interchange Standards Consortium IncAustin | Form 990 | $8,901,903FY2025 |
| Save the StorksPlano | Form 990 | $8,880,049FY2025 |
| Christus Foundation for HealthcareHouston | Form 990 | $8,877,337FY2025 |
| Home for Aged MasonsArlington | Form 990 | $8,588,305FY2025 |
| Umc FoundationLubbock | Form 990 | $8,546,312FY2025 |
| Sky High for Kids IncHouston | Form 990 | $8,266,900FY2024 |
| Texas Diaper BankSan Antonio | Form 990 | $8,161,145FY2025 |
| Waller County Volunteer E M S IncHempstead | Form 990 | $8,097,403FY2025 |
| Planned Parenthood South TexasSan Antonio | Form 990 | $8,009,133FY2024 |
| The Menninger Clinic FoundationHouston | Form 990 | $7,452,491FY2024 |
| Tejas Health CareLa Grange | Form 990 | $7,297,499FY2025 |
| Scottys House Brazos Valley Child Advocacy Center IncBryan | Form 990 | $7,271,636FY2025 |
| Healthconnect TexasHouston | Form 990 | $7,137,738FY2024 |
| Adventhealth Family Medicine Rural Health Clinics IncLampasas | Form 990 | $6,997,199FY2024 |
| Alzheimers Care and Research Center FoundationSan Antonio | Form 990 | $6,848,725FY2025 |
| Voom FoundationCollege Station | Form 990 | $6,658,514FY2025 |
| Pediatric Academic Societies IncThe Woodlands | Form 990 | $6,611,298FY2025 |
| Hospice of Texarkana IncTexarkana | Form 990 | $6,561,408FY2025 |
| Angel Flight IncAddison | Form 990 | $6,524,107FY2024 |
| South Lake Houston Emergency Medical ServicesHouston | Form 990 | $6,334,917FY2022 |
| Capital Area Trauma Regional Advisory CouncilCedar Park | Form 990 | $6,311,397FY2025 |
| Mt Enterprise Community Health ClinicMount Enterprise | Form 990 | $6,067,233FY2024 |
| Vida y Salud-Health Systems IncCrystal City | Form 990 | $5,910,378FY2026 |
| Ronald McDonald House Charities of Central Texas IncAustin | Form 990 | $5,819,048FY2024 |
| Texoma Health FoundationDenison | Form 990 | $5,786,468FY2025 |
| Sistema Infantil Teleton USASan Antonio | Form 990 | $5,777,667FY2024 |
| Austin Lifecare IncAustin | Form 990 | $5,583,223FY2024 |
| Hope Clinic of Garland IncGarland | Form 990 | $5,513,386FY2024 |
| BBG Advanced TherapiesSan Antonio | Form 990 | $5,427,037FY2024 |
| Covenant Health System FoundationLubbock | Form 990 | $5,420,360FY2024 |
| Marble Falls Area Emergency Medical ServiceMarble Falls | Form 990 | $5,269,896FY2025 |
| Methodist Patient Centered AcoDallas | Form 990 | $5,143,597FY2025 |
| First Baptist Denton Ministry CenterDenton | Form 990 | $5,091,454FY2024 |
| Casa Esperanza IncLiberty Hill | Form 990 | $5,051,273FY2025 |
| Health Equity Foundation of Greater TexasDallas | Form 990 | $5,016,963FY2024 |
| Irving Healthcare FoundationIrving | Form 990 | $5,016,628FY2025 |
| Ronald McDonald House Charities South TexasCorpus Christi | Form 990 | $5,006,194FY2024 |