| Texas Childrens Urgent CareBellaire | Form 990 | $31,025,412FY2025 |
| Society of St Vincent de Paul Charitable Pharmacy of North TexasDallas | Form 990 | $30,223,941FY2025 |
| National Breast Cancer Foundation IncFrisco | Form 990 | $29,928,629FY2025 |
| Harris Health Strategic FundBellaire | Form 990 | $29,179,039FY2025 |
| United Regional Physician GroupWichita Falls | Form 990 | $28,750,519FY2024 |
| Methodist Hospital LevellandLevelland | Form 990 | $27,468,176FY2024 |
| Centro de Salud Familiar La Fe IncEl Paso | Form 990 | $26,802,015FY2024 |
| Fort Bend Family Health Center IncRichmond | Form 990 | $26,663,592FY2025 |
| Spring Branch Community Health CenterKaty | Form 990 | $25,691,370FY2024 |
| Planned Parenthood Gulf Coast IncHouston | Form 990 | $24,755,447FY2025 |
| American Religious Town Hall Meeting IncDallas | Group return | $23,853,614FY2024 |
| Parkland FoundationDallas | Form 990 | $23,161,710FY2025 |
| Texas Health Back CareDallas | Form 990 | $22,766,079FY2024 |
| Christus Childrens FoundationSan Antonio | Form 990 | $22,380,471FY2025 |
| Paeon Health Services IncAustin | Form 990 | $21,717,880FY2024 |
| Parkland Center for Clinical InnovationDallas | Form 990 | $20,932,051FY2025 |
| The American Board of Obstetrics and Gynecology IncDallas | Form 990 | $20,542,382FY2024 |
| Healing Hands Ministries IncDallas | Form 990 | $19,910,906FY2024 |
| Project Vida Health CenterEl Paso | Form 990 | $19,288,314FY2025 |
| Community Health Service Agency IncGreenville | Form 990 | $19,024,253FY2025 |
| Community Health Centers of South Central Texas IncGonzales | Form 990 | $18,493,455FY2024 |
| Trincare IncIrving | Form 990 | $18,121,574FY2025 |
| Seven Acres Jewish Senior Care Services IncHouston | Form 990 | $17,976,614FY2025 |
| National Center for Farmworker Health IncBuda | Form 990 | $17,148,673FY2024 |
| Womens Health and Family Planning Association of TexasAustin | Form 990 | $17,058,967FY2025 |
| S P J S T Senior LivingTaylor | Form 990 | $16,995,947FY2024 |
| BST Health Services CorpSan Antonio | Form 990 | $16,766,145FY2025 |
| Baptist Memorials MinistriesDallas | Form 990 | $16,745,978FY2024 |
| Easter Seal Rehabilitation Center IncSan Antonio | Form 990 | $16,276,344FY2025 |
| Easter Seals Rio Grande ValleyMcAllen | Form 990 | $15,793,366FY2025 |
| Forefront Living HospiceDallas | Form 990 | $15,728,362FY2025 |
| Agape ClinicDallas | Form 990 | $15,676,474FY2024 |
| Paso del Norte Community FoundationEl Paso | Form 990 | $15,318,884FY2024 |
| Informed Consent Action NetworkAustin | Form 990 | $15,316,305FY2024 |
| Planned Parenthood of GRTR TX Famly Planning & Preventative HLTH ServsDallas | Form 990 | $15,092,625FY2024 |
| Texas Association of Community Health Centers IncAustin | Form 990 | $14,921,231FY2025 |
| Bethesda Health ClinicTyler | Form 990 | $14,733,548FY2025 |
| Institute for Rehabilitation & Research FoundationHouston | Form 990 | $14,545,995FY2025 |
| Ibn Sina Foundation IncHouston | Form 990 | $14,231,400FY2024 |
| Texas Health Medical SupportArlington | Form 990 | $13,535,189FY2024 |
| Coastal Bend Blood CenterCorpus Christi | Form 990 | $13,314,734FY2025 |
| North Central Texas Trauma Regional Advisory Council IncArlington | Form 990 | $12,963,967FY2025 |
| Amistad Community Health Center IncorporatedCorpus Christi | Form 990 | $12,646,625FY2024 |
| South Plains Rural Health Services IncLevelland | Form 990 | $12,413,505FY2025 |
| Umc El Paso Healthcare IncEl Paso | Form 990 | $12,191,363FY2025 |
| Frontera Healthcare NetworkEden | Form 990 | $12,122,360FY2024 |
| North Texas Healthy CommunitiesArlington | Form 990 | $12,113,573FY2024 |
| Houston Community Health Centers IncHouston | Form 990 | $11,718,202FY2024 |
| Access Esperanza Clinics IncMcAllen | Form 990 | $11,444,563FY2025 |
| All Saints Health FoundationDallas | Form 990 | $11,030,477FY2025 |