| PTA South Carolina CongressPelzer | Form 990-EZ | $61,458FY2026 |
| Rock Hill Community TheatreRock Hill | Form 990-EZ | $60,663FY2023 |
| River Springs Elementary PTOIrmo | Form 990-EZ | $60,384FY2026 |
| Union County Rescue SquadUnion | Form 990-EZ | $59,810FY2025 |
| The Shepherds Center of Saint AndrewsColumbia | Form 990-EZ | $59,531FY2025 |
| South Carolina Farm Bureau Educational FoundationColumbia | Form 990 | $59,508FY2025 |
| The Palmetto Association of Independent Schools IncCainhoy | Form 990-EZ | $59,253FY2025 |
| General Federation of Womens Clubs of South CarolinaLexington | Form 990-EZ | $59,147FY2026 |
| Charleston Chinese Academy IncorporatedSummerville | Form 990-EZ | $58,680FY2025 |
| South Carolina Congress of Parents and TeachersSummerville | Form 990-EZ | $58,087FY2025 |
| South Carolina Congress of Parents and TeachersGreenville | Form 990-EZ | $57,736FY2026 |
| Loris Blue Pride ClubLoris | Form 990-EZ | $57,702FY2025 |
| Crime Stoppers Greenville IncGreenville | Form 990 | $57,674FY2025 |
| PTA South Carolina CongressSimpsonville | Form 990-EZ | $57,673FY2025 |
| Friends of the Sumter County LibrarySumter | Form 990-EZ | $57,105FY2025 |
| National Society of the Daughters of the American RevolutionSimpsonville | Form 990-EZ | $56,730FY2025 |
| Little League Baseball IncGreenville | Form 990-EZ | $56,378FY2025 |
| Reaching Your Dream Learning CenterRidgeville | Form 990-EZ | $56,187FY2025 |
| Friends of Florence County Library IncFlorence | Form 990 | $55,984FY2025 |
| Alliance for Economic Development for Georgetown CountyGeorgetown | Form 990-EZ | $55,184FY2025 |
| Alano Club of Myrtle BeachMyrtle Beach | Form 990-EZ | $54,135FY2024 |
| McBee Rescue Squad IncMcBee | Form 990-EZ | $54,078FY2024 |
| American Society for Training and DevlopmentColumbia | Form 990-EZ | $53,279FY2025 |
| Durbin Creek Volunteer Fire Department and Resque UnitFountain Inn | Form 990-EZ | $53,209FY2026 |
| Cobblestone Quilters Guild IncNorth Charleston | Form 990-EZ | $52,985FY2025 |
| American Chemical SocietyClemson | Form 990-EZ | $52,824FY2025 |
| PTA South Carolina CongressFountain Inn | Form 990-EZ | $51,997FY2025 |
| PTA South Carolina CongressGreenville | Form 990-EZ | $51,982FY2025 |
| PTA South Carolina CongressGreer | Form 990-EZ | $51,965FY2025 |
| Parent Booster USA IncBlythewood | Form 990-EZ | $51,753FY2026 |
| Pickens County Historical SocietyPickens | Form 990-EZ | $51,413FY2025 |
| PTA South Carolina CongressGreer | Form 990-EZ | $51,145FY2025 |
| South Carolina Congress of Parents and TeachersTravelers Rest | Form 990-EZ | $51,008FY2025 |
| Friends of the Beaufort County LibraryBeaufort | Form 990-EZ | $50,834FY2024 |
| South Carolina Genealogical Society IncColumbia | Form 990-EZ | $50,648FY2025 |
| PTA South Carolina CongressGreenville | Form 990-EZ | $50,357FY2026 |
| Missionary Transport IncLancaster | Form 990-EZ | $50,198FY2025 |
| Sons of Confederate Veterans IncCayce | Form 990-EZ | $50,127FY2025 |
| Amateur Athletic Union of the United StatesColumbia | Form 990-N | No figure |
| American Planning AssociationRock Hill | Form 990-N | No figure |
| South Carolina Congress of Parents and TeachersClemson | Form 990-EZ | $47,196FY2026 |
| South Carolina Federation of Music ClubsEnoree | Form 990-N | No figure |
| Historic Ricefields Association IncPawleys Island | Form 990-N | No figure |
| Strokes Fore Progress IncTravelers Rest | Form 990-N | No figure |
| The Living Wright FoundationColumbia | Form 990-N | No figure |
| Favor FoundationLadson | Form 990-N | No figure |
| South Carolina Congress of Parents and TeachersSummerville | Form 990-EZ | $45,208FY2025 |
| Alano Club of the Piedmont AreaGreenville | Form 990-N | No figure |
| PTA South Carolina CongressTravelers Rest | Form 990-EZ | $44,845FY2025 |
| PTA South Carolina CongressSummerville | Form 990-EZ | $44,815FY2025 |