| Blue Ridge Community Health Services IncHendersonville | Form 990 | $81,798,731FY2025 |
| Grow Early Learning CorpRaleigh | Form 990 | $79,457,527FY2024 |
| The Foundation of the University of North Carolina at Charlotte IncCharlotte | Form 990 | $61,259,638FY2025 |
| Hospice of Wake County IncRaleigh | Form 990 | $58,969,226FY2025 |
| Arbor Acres United Methodist Retirement Community IncWinston-Salem | Form 990 | $58,950,328FY2025 |
| Thompson Child & Family FocusMatthews | Form 990 | $49,426,929FY2025 |
| Hospice of Henderson County IncFlat Rock | Form 990 | $48,440,474FY2025 |
| Aldersgate United Methodist Retirement Community IncCharlotte | Form 990 | $47,215,556FY2024 |
| Early Years IncChapel Hill | Form 990 | $42,200,134FY2025 |
| Opportunities Industrialization Center IncRocky Mount | Form 990 | $37,158,746FY2025 |
| Habitat for Humanity International IncRaleigh | Form 990 | $35,867,635FY2025 |
| Young Men Christian Association of Western North CarolinaAsheville | Form 990 | $32,553,562FY2025 |
| Autism Society of North Carolina IncRaleigh | Form 990 | $32,526,782FY2025 |
| Hospice of the Piedmont IncHigh Point | Form 990 | $27,788,615FY2024 |
| United States Baseball Federation IncCary | Form 990 | $26,531,977FY2025 |
| North Carolina Coastal Federation IncNewport | Form 990 | $25,171,726FY2024 |
| Mountain Projects IncWaynesville | Form 990 | $23,698,985FY2025 |
| Triangle Residential Options for Substance Abusers IncDurham | Form 990 | $22,537,137FY2025 |
| Dhic IncRaleigh | Form 990 | $22,132,443FY2024 |
| Capital Area Soccer League IncRaleigh | Form 990 | $21,670,193FY2025 |
| Elderhaus IncorporatedWilmington | Form 990 | $19,910,616FY2025 |
| Cape Fear Tutoring IncWilmington | Form 990 | $19,323,290FY2025 |
| Lutheran Retirement Center Wilmington IncSalisbury | Form 990 | $19,016,937FY2025 |
| Child Care Resources IncCharlotte | Form 990 | $18,757,270FY2025 |
| Anuvia Prevention and Recovery Center IncCharlotte | Form 990 | $16,905,096FY2025 |
| Hot Springs Health Program IncMarshall | Form 990 | $16,510,884FY2025 |
| Community Revitalization and Reservation CorporationRaleigh | Form 990 | $15,964,324FY2024 |
| Aging Disability & Transit Services of Rockingham CountyReidsville | Form 990 | $14,415,302FY2025 |
| Miracles in SightWinston-Salem | Form 990 | $14,310,108FY2024 |
| Hospice of Davidson County North Carolina IncLexington | Form 990 | $14,295,231FY2025 |
| Marbles Kids MuseumRaleigh | Form 990 | $12,969,491FY2025 |
| International Society on Thrombosis and Haemostasis IncCharlotte | Form 990 | $12,803,951FY2025 |
| Eliada Homes IncAsheville | Form 990 | $12,761,457FY2025 |
| Hospice & Palliative Care of the Blue Ridge IncSpruce Pine | Form 990 | $12,400,770FY2025 |
| Freedom House Recovery Center IncChapel Hill | Form 990 | $11,772,262FY2025 |
| Holy Angels IncBelmont | Form 990 | $11,699,968FY2025 |
| Rosedale Health and Wellness PCHuntersville | Form 990 | $11,440,130FY2025 |
| Onslow Community Outreach IncJacksonville | Form 990 | $11,427,103FY2024 |
| Ronald McDonald House Charities of the TriangleDurham | Form 990 | $11,242,499FY2025 |
| North Carolina School of Science & Mathematics FoundationDurham | Form 990 | $11,188,433FY2025 |
| Nash-Edgecombe Wilson Community Action IncRocky Mount | Form 990 | $11,067,577FY2025 |
| Gaston County Family YMCAGastonia | Form 990 | $10,642,492FY2025 |
| Southwestern Child Development Commission IncWebster | Form 990 | $10,370,073FY2025 |
| Missionary Athletes InternationalCharlotte | Form 990 | $10,196,769FY2026 |
| Johnston-Lee-Harnett Community Action IncorporatedSmithfield | Form 990 | $10,072,796FY2025 |
| Central Intercollegiate Athletic AssnCharlotte | Form 990 | $10,053,102FY2025 |
| Durham-Chapel Hill Jewish FederationDurham | Form 990 | $9,992,482FY2025 |
| MDC IncDurham | Form 990 | $9,881,455FY2025 |
| Hospice of Rockingham County IncReidsville | Form 990 | $9,702,938FY2025 |
| Resources for SeniorsRaleigh | Form 990 | $9,646,673FY2025 |