| Southwest Research InstituteSan Antonio | Form 990 | $978,595,721FY2025 |
| Blueforge AllianceBryan | Form 990 | $731,167,389FY2025 |
| Botanical Research Institute of Texas IncFort Worth | Form 990 | $20,491,336FY2025 |
| Fajr ScientificHouston | Form 990 | $18,174,508FY2024 |
| Society of Petroleum Engineers Spe IncRichardson | Form 990 | $15,423,647FY2025 |
| Institute for Creation ResearchDallas | Form 990 | $10,363,954FY2025 |
| Numfocus IncAustin | Form 990 | $8,376,226FY2024 |
| Houston Advanced Research CenterSpring | Form 990 | $7,838,125FY2024 |
| Brink Technology IncAustin | Form 990 | $6,733,129FY2024 |
| Free Code Camp IncPlano | Form 990 | $2,986,509FY2024 |
| Texas Energy Poverty Research InstituteAustin | Form 990 | $1,921,162FY2024 |
| Edge Institute IncAustin | Form 990 | $1,801,537FY2024 |
| Responsible Artificial Intelligence InstituteAustin | Form 990 | $1,743,850FY2024 |
| Geeks Without FrontiersAustin | Form 990 | $1,525,612FY2024 |
| Women in Bio IncDallas | Form 990 | $1,502,370FY2025 |
| Science Teachers Association of TexasAustin | Form 990 | $1,393,298FY2025 |
| The Center for the Research of Early Christian DocumentsPlano | Form 990 | $1,044,092FY2024 |
| Dallas MakerspaceCarrollton | Form 990 | $963,294FY2024 |
| Texas Biomedical ForumSan Antonio | Form 990 | $911,909FY2025 |
| American Society of Civil EngineersAustin | Form 990 | $878,589FY2025 |
| Southwestern Petroleum Short Course Association IncLubbock | Form 990 | $833,756FY2025 |
| Accelerator Research LaboratoryCollege Station | Form 990 | $597,965FY2025 |
| At Conference InternationalPearland | Form 990 | $565,716FY2025 |
| International Conference on Environmental Systems IncLeague City | Form 990 | $521,421FY2025 |
| Commit-Boost IncAustin | Form 990 | $508,505FY2025 |
| American Society of Parasitologists Inc a New Mexico Nonprofit CorpoHuntsville | Form 990 | $435,656FY2025 |
| Center for Maximum Potential Building Systems IncAustin | Form 990 | $430,216FY2025 |
| Geophysical Society of HoustonHouston | Form 990 | $405,796FY2025 |
| Alliance for Pathways Into EngineeringAustin | Form 990 | $399,285FY2025 |
| Houston Gas Processors AssociationHouston | Form 990 | $387,388FY2025 |
| Austin Science Education FoundationAustin | Form 990 | $382,494FY2025 |
| Research Theory IncAustin | Form 990 | $377,429FY2025 |
| Otree Open Source Research FoundationHouston | Form 990 | $364,670FY2025 |
| Dallas Alliance of Technology & WomenIrving | Form 990 | $328,074FY2025 |
| Corpus Christi Geological Library IncCorpus Christi | Form 990 | $308,540FY2025 |
| Fomares IncHouston | Form 990 | $306,272FY2025 |
| Youth Code Jam San AntonioSan Antonio | Form 990 | $300,995FY2024 |
| Association of Space Explorers USAWebster | Form 990 | $288,370FY2024 |
| San Antonio Community Resource DirectorySan Antonio | Form 990 | $279,408FY2024 |
| International Behavioral Neuroscience SocietyBandera | Form 990 | $279,006FY2025 |
| High-Tech High HeelsDallas | Form 990 | $278,567FY2025 |
| Black Girls Do Engineer CorporationWebster | Form 990 | $271,994FY2025 |
| Institute for Leadership in Capital ProjectsSeguin | Form 990 | $267,428FY2024 |
| Rainforest ConnectionKaty | Form 990 | $251,293FY2024 |
| Aldrin Family Foundation of TexasAustin | Form 990 | $243,620FY2025 |
| TalkstemDallas | Form 990 | $213,328FY2024 |
| Texas Marine Mammal Stranding NetworkGalveston | Form 990 | $207,480FY2024 |
| Adagio Institute IncHouston | Form 990 | $200,893FY2024 |
| Society of Chinese Bioscientists in AmericaBellaire | Form 990 | $199,648FY2025 |
| Houston Hispanic Architects & Engineers Society IncHouston | Form 990 | $173,582FY2024 |