| Alliance for Substance Abuse Prevention IncRapid City | Form 990-EZ | $116,559FY2025 |
| The Rapid City Public School Foundation IncRapid City | Form 990 | $116,018FY2025 |
| Lake County Food Pantry IncMadison | Form 990-EZ | $115,920FY2025 |
| Senior Companion FundSioux Falls | Form 990 | $112,456FY2025 |
| Minn-Kota Mennonite Central Committee Relief Sale IncFreeman | Form 990-EZ | $103,866FY2024 |
| South Dakota Counseling Association IncPlatte | Form 990-EZ | $103,295FY2025 |
| Higher Power SportsParkston | Form 990-EZ | $101,838FY2025 |
| Association of SD Weed & Pest BoardsWolsey | Form 990-EZ | $101,792FY2025 |
| Domestic Violence Safe Options ServicesVermillion | Form 990-EZ | $98,389FY2024 |
| Council on College Admission in South DakotaBelle Fourche | Form 990-EZ | $97,338FY2025 |
| Empire Mental Health SupportSioux Falls | Form 990-EZ | $96,421FY2025 |
| Custer County Senior Citizens ClubCuster | Form 990-EZ | $95,107FY2025 |
| Sioux Empire Home Builders Care FoundationSioux Falls | Form 990 | $91,497FY2024 |
| National Society of the Daughters of the American RevolutionSioux Falls | Form 990-EZ | $87,937FY2025 |
| Town PlayersWatertown | Form 990-EZ | $86,447FY2025 |
| Sioux Falls Arts CouncilSioux Falls | Form 990-EZ | $85,594FY2025 |
| Verendrye Museum IncorporatedFort Pierre | Form 990 | $84,494FY2025 |
| Weskota ApartmentsWessington Springs | Form 990-EZ | $84,047FY2025 |
| Festival of Bands - U S ASioux Falls | Form 990-EZ | $83,085FY2025 |
| Region Viii Head Start AssociationNew Holland | Form 990-EZ | $81,066FY2025 |
| Gregory Community ServicesGregory | Form 990-EZ | $80,311FY2025 |
| Moody County Historical SocietyFlandreau | Form 990-EZ | $79,203FY2025 |
| Union County Historical SocietyElk Point | Form 990 | $76,502FY2024 |
| South Dakota Right to Life Committee Educational FundSioux Falls | Form 990-EZ | $74,908FY2025 |
| Sisseton Swimming Pool Association IncSisseton | Form 990-EZ | $73,859FY2024 |
| Eureka Community Development Co IncEureka | Form 990-EZ | $73,275FY2025 |
| Mellette Memorial AssociationWatertown | Form 990 | $72,757FY2024 |
| Pierre Area Senior Citizens CenterPierre | Form 990-EZ | $68,087FY2025 |
| Washington Senior High School Booster ClubSioux Falls | Form 990-EZ | $67,632FY2025 |
| USA Swimming IncMitchell | Form 990-EZ | $66,271FY2025 |
| Live Center Residential IncLemmon | Form 990-EZ | $61,622FY2025 |
| Fall River County Historical Society Route No 1Hot Springs | Form 990 | $61,452FY2025 |
| Laura Ingalls Wilder Pageant SocietyDe Smet | Form 990-EZ | $61,082FY2024 |
| South Dakota Congress of Parents and TeachersBrandon | Form 990-EZ | $59,261FY2026 |
| Crystal Theatre Cultural AssociationFlandreau | Form 990-EZ | $58,490FY2025 |
| Garden City Volunteer Firefighters IncGarden City | Form 990 | $54,298FY2025 |
| Historic Deadwood Lead Arts CouncilLead | Form 990-EZ | $52,131FY2024 |
| Habitat for Humanity International IncMitchell | Form 990-EZ | $50,025FY2026 |
| Hill City Senior Citizens CenterHill City | Form 990-EZ | $49,444FY2025 |
| Schoolhouse DaycareVeblen | Form 990-N | No figure |
| Rural Ethnic InstituteRapid City | Form 990-N | No figure |
| Prairie Payee Services IncSioux Falls | Form 990-N | No figure |
| Yaks Give Back FoundationSioux Falls | Form 990-EZ | $36,053FY2025 |
| Road Runners Club of AmericaRapid City | Form 990-EZ | $31,951FY2025 |
| Little League Baseball IncBox Elder | Form 990-N | No figure |
| Midland Area Emergency Medical ServiceMidland | Form 990-N | No figure |
| Jobs Daughters InternationalAberdeen | Form 990-N | No figure |
| South Dakota Society of Fire Service InstructorsYankton | Form 990-EZ | $27,613FY2025 |
| Deuel Area Development IncClear Lake | Form 990-N | No figure |
| Redfield Ringneck AssociationRedfield | Form 990-EZ | $13,477FY2025 |