| The Masterworks Choir IncFlorence | Form 990 | $298,813FY2026 |
| Parents and Guardians Association of the Costal CenterSummerville | Form 990 | $295,488FY2025 |
| Daily Bread Ministries IncGreer | Form 990 | $287,946FY2025 |
| Good Samaritan ColonyRuby | Form 990 | $284,922FY2024 |
| Pickens County Habitat for HumanityClemson | Form 990 | $280,007FY2024 |
| Magnolia Memory Care IncFort Mill | Form 990 | $276,624FY2024 |
| Beyond HousingGreenville | Form 990 | $276,564FY2024 |
| Palmetto State Arts EducationGreenwood | Form 990 | $271,167FY2025 |
| Clebe McClary Evangelistic AssociationPawleys Island | Form 990 | $267,534FY2024 |
| Catawba Community Mental Health Foundation IncRock Hill | Form 990 | $264,716FY2025 |
| Tomorrows America Foundation IncClover | Form 990 | $261,759FY2024 |
| Westover Apartments IncCharleston | Form 990 | $260,698FY2025 |
| Little League Baseball IncGreenville | Form 990 | $259,747FY2025 |
| Honor Health Career ProgramsAnderson | Form 990 | $258,970FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $258,231FY2025 |
| Association for Pre- and Perinatal Psychology and HealthMarietta | Form 990 | $256,950FY2023 |
| Carolina Marathon Association IncColumbia | Form 990 | $255,036FY2025 |
| Hibernian Society of Charleston Foundation IncCharleston | Form 990 | $252,029FY2025 |
| Association for Supervision and Curriculum DevelopmentMoncks Corner | Form 990 | $251,498FY2025 |
| Western Piedmont Education ConsortiumGreenwood | Form 990 | $247,920FY2025 |
| Spartanburg Science CenterSpartanburg | Form 990 | $245,128FY2025 |
| Bethel Volunteer Fire Department IncClover | Form 990 | $240,794FY2024 |
| 864PRIDEGreenville | Form 990 | $239,731FY2025 |
| International College Learning Center Association IncColumbia | Form 990 | $237,914FY2024 |
| Friends of the Aiken County Public LibraryAiken | Form 990 | $237,177FY2025 |
| South Carolina Congress of Parents and TeachersDaniel Island | Form 990 | $236,986FY2025 |
| The Turning Point of ChesterChester | Form 990 | $235,837FY2025 |
| Orange-Calhoun-Allendale-Bamberg Community Development CorporationOrangeburg | Form 990 | $234,707FY2024 |
| PTA South Carolina CongressMount Pleasant | Form 990 | $234,239FY2025 |
| The Trojan Club IncRock Hill | Form 990 | $233,453FY2026 |
| Boys Club of AmericaOrangeburg | Form 990 | $230,363FY2025 |
| River Hills Lake Wylie Lions Charities IncLake Wylie | Form 990 | $226,145FY2025 |
| Homeland Park Fire Department IncAnderson | Form 990 | $222,836FY2025 |
| Church Planting InternationalFort Mill | Form 990 | $222,759FY2024 |
| Little League Baseball IncTaylors | Form 990 | $221,647FY2025 |
| South Carolina Artisans CenterWalterboro | Form 990 | $218,576FY2025 |
| Columbia Classical Ballet CoColumbia | Form 990 | $215,431FY2025 |
| Social Emotional Learning Alliance for South CarolinaMount Pleasant | Form 990 | $215,228FY2024 |
| Carolina Place IncRock Hill | Form 990 | $214,398FY2024 |
| Mental Health America of South CarolinaAiken | Form 990 | $214,386FY2025 |
| Mother Deveaux Adult Day CareEastover | Form 990 | $214,178FY2025 |
| Brennen Elementary School Parent-Teacher Organization PTOColumbia | Form 990 | $213,566FY2025 |
| Family Support Services of Horry County IncConway | Form 990 | $211,635FY2024 |
| Richland East IncWest Columbia | Form 990 | $211,082FY2025 |
| Halfway There RescueRock Hill | Form 990 | $210,140FY2025 |
| PTA South Carolina CongressMount Pleasant | Form 990 | $208,244FY2025 |
| Monday After the Masters Mam Pro-Am Golf Tournament IncColumbia | Form 990 | $207,978FY2025 |
| McCormick Arts Council at the Keturah M A C KMcCormick | Form 990 | $207,746FY2024 |
| Camp Discovery at His Acres IncBlythewood | Form 990 | $207,595FY2024 |
| Dreher High School Athletic Booster ClubColumbia | Form 990 | $207,115FY2025 |