| Lee County Council of Aging IncBishopville | Form 990 | $628,657FY2025 |
| South Carolina Association of Independent Home SchoolsColumbia | Form 990 | $626,520FY2024 |
| Chesterfield County Council on AgingChesterfield | Form 990 | $618,206FY2025 |
| SC Share Self-Help Association Regarding EmotionsCayce | Form 990 | $615,694FY2026 |
| South Carolina Midlands Emergency Medical Serv Management AssnWest Columbia | Form 990 | $606,975FY2025 |
| Amelia Village Housing CorporationGreenville | Form 990 | $600,754FY2025 |
| Art League of Hilton Head Island IncHilton Head | Form 990 | $595,098FY2025 |
| Precious One Learning Center IncFlorence | Form 990 | $593,550FY2025 |
| Silver Lining Arts Foundation IncMyrtle Beach | Form 990 | $592,638FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $591,820FY2025 |
| Palmetto Citizens Against Sexual AssaultLancaster | Form 990 | $574,977FY2025 |
| United Way of Sumter Clarendon and Lee Counties IncSumter | Form 990 | $570,882FY2025 |
| Rock Hill School District FoundationRock Hill | Form 990 | $569,289FY2025 |
| United Way of Laurens County IncClinton | Form 990 | $565,911FY2025 |
| South Carolina Council on Economic EducationColumbia | Form 990 | $563,019FY2025 |
| National Wild Turkey Federation Research Foundation IncEdgefield | Form 990 | $551,492FY2024 |
| New Day Inc of SpartanburgSpartanburg | Form 990 | $551,407FY2025 |
| Fork Shoals Historical SocietyPelzer | Form 990 | $549,106FY2024 |
| Greenville Urban League Seniors HouseGreenville | Form 990 | $540,846FY2024 |
| Road Runners Club of AmericaGreenville | Form 990 | $538,538FY2025 |
| Live Free IncPelzer | Form 990 | $534,782FY2025 |
| Lean Ensemble TheaterHilton Head | Form 990 | $526,628FY2025 |
| Roper Mountain Science Center AssociationGreenville | Form 990 | $517,883FY2025 |
| South Carolina Railroad Museum IncColumbia | Form 990 | $515,823FY2025 |
| The Family Resource CenterCamden | Form 990 | $514,070FY2025 |
| Meals on Wheels Bluffton Hilton Head IncHilton Head | Form 990 | $511,797FY2025 |
| Slater Marietta Health and Human Services IncSlater | Form 990 | $501,112FY2025 |
| The Shepherds Fold IncRock Hill | Form 990 | $499,523FY2025 |
| Association of School Business Officials InternationalColumbia | Form 990 | $497,412FY2026 |
| Rize Prevention IncMauldin | Form 990 | $497,197FY2025 |
| Parent Booster USA IncDuncan | Form 990 | $489,631FY2025 |
| American Forage and Grassland CouncilBlythewood | Form 990 | $471,025FY2025 |
| Bethel Christian Camp and Retreat CenterGaston | Form 990 | $470,648FY2025 |
| Historic Bluffton FoundationBluffton | Form 990 | $466,843FY2025 |
| Halter Heal & Learn Through Equine RelationshipsSpartanburg | Form 990 | $462,112FY2025 |
| Palmetto Electric TrustRidgeland | Form 990 | $460,709FY2024 |
| Sumter County Museum FoundationSumter | Form 990 | $455,885FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $451,198FY2025 |
| Sea Turtle Patrol Hilton Head IslandHilton Head | Form 990 | $450,473FY2025 |
| Lancaster County Society for Historical Preservation IncLancaster | Form 990 | $446,344FY2025 |
| Health Occupations Students of AmericaAiken | Form 990 | $441,440FY2025 |
| Birthright of Greenville IncGreenville | Form 990 | $440,962FY2025 |
| Congaree Rapid FCWest Columbia | Form 990 | $437,067FY2024 |
| NAMI Mid-CarolinaColumbia | Form 990 | $435,978FY2024 |
| Vantage Point FoundationCharleston | Form 990 | $430,946FY2024 |
| USA Swimming IncClover | Form 990 | $427,875FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $427,610FY2025 |
| Flowertown Players IncSummerville | Form 990 | $425,801FY2025 |
| Association of Southeastern BiologistsNewberry | Form 990 | $419,906FY2025 |
| South Carolina Citizens for Life IncColumbia | Form 990 | $419,259FY2024 |