| Lowcountry Food Bank IncCharleston | Form 990 | $90,109,996FY2024 |
| CLC Administrative Services IncSpartanburg | None required | $29,927,307FY2024 |
| Rolling Green VillageGreenville | Form 990 | $29,139,579FY2024 |
| Tri-Development Center of Aiken CountyAiken | Form 990 | $22,801,533FY2025 |
| Rural Health Services IncAiken | Form 990 | $21,334,362FY2025 |
| Saluda County Nursing Home Board Saluda Nursing CenterSaluda | Form 990 | $20,791,894FY2025 |
| York County Board of Disabilities and Special NeedsYork | Form 990 | $19,938,245FY2025 |
| Pee Dee Community Action AgencyFlorence | Form 990 | $18,837,464FY2024 |
| Community Medicine FoundationRock Hill | Form 990 | $18,076,938FY2025 |
| Family Health Centers IncOrangeburg | Form 990 | $17,752,657FY2025 |
| University of South Carolina Business Partnership FoundationColumbia | Form 990 | $17,296,737FY2025 |
| Hospice of the Upstate IncAnderson | Form 990 | $14,925,884FY2025 |
| Lowcountry AIDS ServicesNorth Charleston | Form 990 | $14,015,383FY2024 |
| Alston Wilkes SocietyColumbia | Form 990 | $13,685,008FY2024 |
| Community Services for the Aging IncSpartanburg | Form 990 | $13,146,842FY2025 |
| Aid UpstateGreenville | Form 990 | $12,186,283FY2024 |
| United Way of Greenville County IncorporatedGreenville | Form 990 | $12,183,207FY2024 |
| South Carolina Association of Community Action PartnershipsColumbia | Form 990 | $11,844,037FY2025 |
| Beaufort Jasper Economic Opportunity Commission IncBeaufort | Form 990 | $11,562,154FY2024 |
| Aiken Barnwell Counties Community Action Agency IncAiken | Form 990 | $10,710,694FY2025 |
| Young Mens Christian Association of Greater SpartanburgSpartanburg | Form 990 | $10,187,358FY2025 |
| Pickens County Young Mens Christian AssociationEasley | Form 990 | $9,547,021FY2025 |
| Horry County Commission on Alcohol and Drug AbuseConway | Form 990 | $8,606,045FY2025 |
| Hospice and Palliative Care of the Piedmont IncGreenwood | Form 990 | $8,394,438FY2025 |
| South Carolina State University Foundation IncOrangeburg | Form 990 | $8,339,017FY2024 |
| Carolina Community Care IncRock Hill | Form 990 | $8,305,118FY2025 |
| Mental Illness Recovery Center IncColumbia | Form 990 | $7,704,600FY2025 |
| Greenville Free Medical ClinicGreenville | Form 990 | $7,653,489FY2025 |
| York County Council on Alcohol and Drug Abuse IncRock Hill | Form 990 | $7,309,934FY2025 |
| Mirasol Health IncBluffton | Form 990 | $6,901,267FY2025 |
| South Carolina High School LeagueColumbia | Form 990 | $6,873,703FY2025 |
| Palmetto AIDS Life Support ServicesColumbia | Form 990 | $6,728,456FY2025 |
| Meyer Center for Special ChildrenGreenville | Form 990 | $6,638,456FY2025 |
| Habitat for Humanity International IncJohns Island | Form 990 | $6,492,792FY2025 |
| Special Olympics South CarolinaLexington | Form 990 | $5,889,992FY2024 |
| Pickens County Commission on Alcohol and Drug AbuseEasley | Form 990 | $5,876,174FY2025 |
| Pee Dee Coalition Against Domestic and Sexual AssaultFlorence | Form 990 | $5,849,023FY2025 |
| Summerville Family Young Mens Christian AssociationSummerville | Form 990 | $5,568,304FY2024 |
| Academy of ArtsTaylors | Form 990 | $5,518,745FY2025 |
| United Way of the Piedmont IncSpartanburg | Form 990 | $5,403,229FY2025 |
| Hope Center for ChildrenSpartanburg | Form 990 | $5,316,973FY2025 |
| Boys & Girls Clubs of the Crescent RegionColumbia | Form 990 | $5,268,550FY2025 |
| University of South Carolina Upstate FoundationSpartanburg | Form 990 | $5,262,784FY2025 |
| The Dee Norton Lowcountry Childrens Center IncCharleston | Form 990 | $5,242,345FY2026 |
| Childrens Attention Home IncRock Hill | Form 990 | $5,234,405FY2025 |
| Hilton Head Island Recreation AssociationHilton Head | Form 990 | $5,213,600FY2025 |
| Family Services IncNorth Charleston | Form 990 | $5,140,512FY2025 |
| Tricounty Commission on Alcohol and Drug AbuseOrangeburg | Form 990 | $4,978,672FY2025 |
| The Arc of South CarolinaLexington | Form 990 | $4,933,459FY2025 |
| Child Freedom Coalition IncGreenville | Form 990 | $4,924,525FY2025 |