| Advanced Technology InternationalSummerville | Form 990 | $4,870,021,886FY2025 |
| South Carolina Research AuthorityColumbia | None required | $16,234,461FY2023 |
| One Nation InnovationColumbia | Form 990 | $12,977,213FY2024 |
| SC ThriveColumbia | Form 990 | $7,968,689FY2025 |
| University Industry Demonstration Partnership IncColumbia | Form 990 | $4,251,434FY2025 |
| Palmetto Innosphere IncPiedmont | Form 990 | $384,000FY2025 |
| Charleston Center for PaleontologyCharleston | Form 990 | $221,021FY2024 |
| National Science and Engineering Alliance IncLake City | Form 990-EZ | $97,516FY2024 |
| VC ExpeditionsCharleston | Form 990-EZ | $85,000FY2025 |
| South Coast Cyber Center IncBeaufort | Form 990-EZ | $82,596FY2025 |
| Innovision Awards OrganizationGreenville | Form 990-EZ | $76,585FY2025 |
| American Chemical SocietyAiken | Form 990 | $71,283FY2025 |
| CDC Education FoundationCharleston | Form 990-EZ | $65,499FY2025 |
| Archeological Institute of the Pee DeeFlorence | Form 990-EZ | $58,300FY2025 |
| International Mechanical Diagnosis and Therapy Research FoundationBlythewood | Form 990 | $22,967FY2025 |
| SC Division of the International Association for IdentificationCharleston | Form 990-N | No figure |
| Scbio FoundationGreenville | Form 990-N | No figure |
| Building Enclosure Council -CharlestonSummerville | Form 990-N | No figure |
| Southeastern Universities Nuclear Reactors Institute for Science andAiken | Form 990-N | No figure |
| Savannah River Section of the Amer Nuclear Society Incorporated TermAiken | Form 990-N | No figure |
| Technology Research ServicesColumbia | Form 990-N | No figure |
| South Carolina Archaeology Public Outreach Division IncColumbia | Form 990-N | No figure |
| Wikiciv Org IncGreenville | Form 990-N | No figure |
| National Society of Black EngineersNorth Augusta | Form 990-N | No figure |
| Gaming for Hope IncConway | Form 990-N | No figure |
| Comprehensive Community Based Solutions IncRock Hill | Form 990-N | No figure |
| Ascue IncConway | Form 990-N | No figure |
| Symposium on Stimuli-Responsive MaterialsClemson | Form 990-N | No figure |
| National Society of Black EngineersNorth Charleston | Form 990-N | No figure |
| ISC2 Charleston ChapterDaniel Island | Form 990-N | No figure |
| National Society of Black EngineersColumbia | Form 990-N | No figure |
| South Carolina Society of Nuclear MedicineWest Columbia | Form 990-N | No figure |
| Cola MakerspaceColumbia | Form 990-N | No figure |
| South Carolina Entomological SocietyColumbia | Form 990-N | No figure |
| Midlands Astronomy Club IncColumbia | Form 990-N | No figure |
| Lowcountry StargazersCharleston | Form 990-N | No figure |
| Lowcountry Institute for Future Technologies IncSheldon | Form 990-N | No figure |
| South Carolina Academy of ScienceColumbia | Form 990-N | No figure |
| Carolina Institute of TechnologyColumbia | Form 990-N | No figure |
| Hands on Prosthetic Engineering HopeColumbia | Form 990-N | No figure |
| Millyard Operations Technical Advancement GroupLexington | Form 990-N | No figure |
| Foundation for Southeastern Fish and Wildlife AgenciesAiken | Form 990-N | No figure |
| Lowcountry STEM CollaborativeCharleston | Form 990-N | No figure |
| Ernest Everett Just Charleston ChapterMount Pleasant | Form 990-N | No figure |
| Beyond the LectureSimpsonville | Form 990-N | No figure |
| Eco 180Inman | Form 990-N | No figure |
| Design Build Fly at ClemsonColumbia | Form 990-N | No figure |
| Women Life and ScienceGreenville | Form 990-N | No figure |
| Association for Computing MachinerySpartanburg | Form 990-N | No figure |
| Upstate South Carolina General Mobile Radio Service Group IncPickens | Form 990-N | No figure |