| Christian Hope Academy IncGaston | Form 990 | $279,675FY2025 |
| Heritage Library Foundation IncHilton Head | Form 990 | $278,317FY2025 |
| Palmetto State Literacy AssociationClinton | Form 990 | $278,096FY2025 |
| Bands of Wando FoundationIsle of Palms | Form 990 | $277,898FY2025 |
| South Carolina Alliance of Black School EducatorsColumbia | Form 990 | $276,857FY2025 |
| Still Water Montessori SchoolLadson | Form 990 | $275,930FY2024 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $272,984FY2025 |
| United Farmers USA IncManning | Form 990 | $272,127FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $270,966FY2025 |
| Edens Community Enrichment FoundationColumbia | Form 990 | $270,772FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $266,490FY2025 |
| Leadership South CarolinaColumbia | Form 990 | $266,266FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $261,828FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $260,746FY2025 |
| Blue Ridge Innovation and Entrepreneurship FoundationClemson | Form 990 | $258,121FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $254,146FY2025 |
| Summerville Green Wave Band Booster ClubSummerville | Form 990 | $253,531FY2025 |
| Parent Booster USA IncPiedmont | Form 990 | $252,649FY2026 |
| Uasc InternationalColumbia | Form 990 | $250,896FY2024 |
| Love House Learning AcademyBeaufort | Form 990 | $246,332FY2025 |
| Harold C Jennings FoundationGreenville | Form 990 | $244,763FY2025 |
| Best Skills AcademyGreenville | Form 990 | $244,315FY2025 |
| Spartanburg High School All Sports Booster ClubSpartanburg | Form 990 | $243,583FY2025 |
| Wilson High School Alumni Association IncorporatedFlorence | Form 990 | $241,844FY2025 |
| Freedom Readers IncMyrtle Beach | Form 990 | $241,642FY2024 |
| Thomas Cario Middle School Band Boosters ClubMount Pleasant | Form 990 | $238,956FY2025 |
| 317 Hybrid School of BlythewoodBlythewood | Form 990 | $238,510FY2026 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $238,446FY2025 |
| Ignite Co-OpClemson | Form 990 | $237,186FY2025 |
| Foundation for Reproductive Genetics Education IncIrmo | Form 990 | $237,155FY2025 |
| Our Saviour Community MinistriesGreenville | Form 990 | $236,826FY2025 |
| Wando All Sports Booster ClubMount Pleasant | Form 990 | $227,534FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesGreenwood | Form 990 | $226,687FY2025 |
| South Carolina First Steps to School Readiness Board of TrusteesBennettsville | Form 990 | $226,603FY2025 |
| Palmetto Literacy CouncilMyrtle Beach | Form 990 | $224,670FY2025 |
| PBC Kidz AcademyPauline | Form 990 | $223,205FY2025 |
| Lexington High School Band BoostersLexington | Form 990 | $220,646FY2025 |
| South Carolina Afterschool AllianceColumbia | Form 990 | $220,286FY2024 |
| River Trail Elementary Parent Teacher OrganizationFort Mill | Form 990 | $219,749FY2025 |
| Frazee CenterEasley | Form 990 | $218,361FY2024 |
| South Carolina Association of Student CouncilsLexington | Form 990 | $215,283FY2026 |
| Ubiquity IncGreer | None required | $214,500FY2014 |
| Latta Schools Educational Foundation IncLatta | Form 990 | $214,261FY2025 |
| Augustine Literacy Project of the Upstate IncMauldin | Form 990 | $213,901FY2025 |
| South Carolina Native Plants SocietyConway | Form 990 | $213,315FY2025 |
| Indian Land Elementary PTOFort Mill | Form 990 | $212,512FY2025 |
| Rotary Club of Aiken FoundationAiken | Form 990 | $212,344FY2025 |
| Palmetto Partners for Science and TechnologyPendleton | Form 990 | $212,162FY2025 |
| Adoption Options IncCharleston | Form 990 | $210,716FY2025 |
| East Cooper Ecumenical Network IncMount Pleasant | Form 990 | $210,619FY2025 |