| Munson Medical GroupTraverse City | Form 990 | $34,227,081FY2025 |
| The Hope FoundationAnn Arbor | Form 990 | $25,657,637FY2025 |
| Health Emergency Assistance of DetroitDetroit | Form 990 | $15,848,565FY2025 |
| National Kidney Foundation IncAnn Arbor | Form 990 | $13,597,000FY2025 |
| Guest House IncLake Orion | Form 990 | $9,663,775FY2025 |
| Kirk H and Joann P Gibson Family Foundation for Parkinsons ResearchFarmington Hills | Form 990 | $7,658,722FY2024 |
| NFXDetroit | Form 990 | $6,883,911FY2024 |
| Autism Alliance of MichiganSouthfield | Form 990 | $4,984,559FY2024 |
| Hemophilia Foundation of MichiganYpsilanti | Form 990 | $4,413,608FY2025 |
| Epilepsy Foundation of MichiganSouthfield | Form 990 | $3,040,333FY2025 |
| American Autoimmune Related Diseases AssociationClinton Township | Form 990 | $2,965,208FY2025 |
| Sickle Cell Disease Association of America Michigan Chapter IncDetroit | Form 990 | $2,596,723FY2025 |
| Pink Fund IncBingham Farms | Form 990 | $2,422,800FY2025 |
| New Day Foundation for FamiliesRochester | Form 990 | $2,275,515FY2024 |
| PoeticeHolland | Form 990 | $2,217,909FY2025 |
| Michigan Parkinson FoundationBingham Farms | Form 990 | $2,008,470FY2024 |
| Team Lafontaine Ucancervive FoundationBloomfield Hills | Form 990 | $1,978,674FY2024 |
| Caribbean Christian Centre for the Deaf IncZeeland | Form 990 | $1,920,278FY2024 |
| Wellness AIDS Services IncBurton | Form 990 | $1,639,166FY2025 |
| National Arab American Medical Association IncTroy | Form 990 | $1,557,970FY2024 |
| Wellness Networks IncDetroit | Form 990 | $1,525,650FY2025 |
| Childrens Leukemia Foundation of MichiganFarmington | Form 990 | $1,457,758FY2025 |
| Michigan United Cerebral PalsySouthfield | Form 990 | $1,012,155FY2025 |
| Michigan Dyslexia Institute IncLansing | Form 990 | $958,290FY2025 |
| Communication Access Center for the Deaf and Hard of Hearing IncFlushing | Form 990 | $935,529FY2024 |
| Cutaneous Lymphoma Foundation IncWarren | Form 990 | $836,833FY2025 |
| Mad-Id IncorporatedTroy | Form 990 | $782,056FY2025 |
| Specialized Language Development CenterPortage | Form 990 | $713,490FY2025 |
| Amyotrophic Lateral Sclerosis Association of Michigan IncSouthfield | Form 990 | $711,678FY2025 |
| Brain Injury Association of Michigan IncorporatedBrighton | Form 990 | $694,920FY2024 |
| Relapsing Polychondritis Awareness and Support FoundationMarquette | Form 990 | $693,706FY2026 |
| AsppireLansing | Form 990 | $663,650FY2024 |
| Great Lakes Recovery Center FoundationNegaunee | Form 990 | $552,655FY2023 |
| Shades of Pink FoundationBirmingham | Form 990 | $540,402FY2024 |
| Association of Interventional Pulmonary Program DirectorsBirmingham | Form 990 | $523,530FY2024 |
| National Council of Dementia MindsOwosso | Form 990 | $478,595FY2024 |
| Dont Forget MeWest Bloomfield | Form 990 | $473,163FY2025 |
| Dynami FoundationBirmingham | Form 990 | $443,653FY2024 |
| American College of NeuropsychiatristsFarmington Hills | Form 990 | $437,505FY2026 |
| Huntingtons Disease Youth Organization of AmericaLivonia | Form 990 | $415,962FY2024 |
| Vision Outreach International IncSaint Joseph | Form 990 | $398,734FY2025 |
| Hope for HieWest Bloomfield | Form 990 | $394,629FY2024 |
| Starlite Shores Family CampByron Center | Form 990 | $390,698FY2025 |
| United Cerebral Palsy Association of MichiganSouthfield | Form 990 | $374,328FY2025 |
| Color of Autism Foundation IncorporatedBeverly Hills | Form 990 | $371,098FY2025 |
| Eosinophilic & Rare Disease CooperativeKentwood | Form 990 | $351,488FY2025 |
| Berrien County Cancer Service IncSaint Joseph | Form 990 | $335,786FY2025 |
| Bonnell Foundation Living with Cystic FibrosisRoyal Oak | Form 990 | $326,825FY2025 |
| Early Intervention CenterBloomfield Hills | Form 990 | $302,085FY2024 |
| Michigan Institute of Urology Mens Health FoundationRochester | Form 990 | $299,686FY2024 |