| Guardian Angel Community ServicesJoliet | Form 990 | $10,500,951FY2025 |
| Oak Leyden Developmental ServicesOak Park | Form 990 | $10,467,620FY2025 |
| Mary Crane LeagueChicago | Form 990 | $10,237,270FY2025 |
| Senior Services Associates IncElgin | Form 990 | $9,941,139FY2025 |
| West Suburban Community Pantry IncWoodridge | Form 990 | $9,875,000FY2025 |
| Central East Alcoholism & Drug CouncilCharleston | Form 990 | $9,869,783FY2025 |
| Boys & Girls Clubs of North Central Illinois IncSouth Elgin | Form 990 | $9,814,302FY2025 |
| Two Rivers YMCA IncMoline | Form 990 | $9,798,758FY2025 |
| Equip for Equality IncChicago | Form 990 | $9,633,716FY2025 |
| Christian Heritage AcademyNorthfield | Form 990 | $9,429,760FY2025 |
| Centers for New Horizons IncChicago | Form 990 | $9,422,603FY2025 |
| Onward Neighborhood HouseChicago | Form 990 | $9,397,459FY2025 |
| Center for Prevention of AbusePeoria | Form 990 | $9,265,056FY2025 |
| Young Mens Christian Assn of SpringfieldSpringfield | Form 990 | $9,105,132FY2024 |
| American Academy of Hospice & Palliative Medicine IncSchaumburg | Form 990 | $9,100,464FY2024 |
| Little Sisters of the Poor Chicago IncChicago | Form 990 | $9,050,224FY2024 |
| Arthroscopy Association of North America IncRosemont | Form 990 | $8,947,868FY2024 |
| Apostolic Christian Home of Roanoke Illinois IncRoanoke | Form 990 | $8,904,879FY2025 |
| Special Childrens CharitiesChicago | Form 990 | $8,886,502FY2024 |
| Center for Research LibrariesChicago | Form 990 | $8,848,692FY2025 |
| Industrial Council of Nearwest ChicagoChicago | Form 990 | $8,822,239FY2024 |
| American Theological Library AssocChicago | Form 990 | $8,769,919FY2025 |
| Illinois Association of Community Action AgenciesSpringfield | Form 990 | $8,639,337FY2025 |
| Young Mens Christian Association of Northwestern Dupage CountyGlen Ellyn | Form 990 | $8,588,712FY2025 |
| Shelby County Community Service IncShelbyville | Form 990 | $8,471,229FY2024 |
| Chicago Cubs CharitiesChicago | Form 990 | $8,349,672FY2025 |
| National Childrens Cancer Society IncBelleville | Form 990 | $8,344,662FY2025 |
| Heart of Illinois United Way IncPeoria | Form 990 | $8,314,424FY2025 |
| Jefferson County ComprehensiveMount Vernon | Form 990 | $8,241,746FY2025 |
| Arden Shore Child and Family ServiceWaukegan | Form 990 | $8,210,571FY2025 |
| Society of Surgical Oncology IncRosemont | Form 990 | $8,179,210FY2025 |
| Orthopedic Trauma Association IncSchaumburg | Form 990 | $8,150,038FY2024 |
| Crosswalk Community Action Agency IncWest Frankfort | Form 990 | $8,144,737FY2025 |
| Greater West Town Community Development ProjectChicago | Form 990 | $8,133,501FY2025 |
| American Society of Colon & Rectal SurgeonsBannockburn | Form 990 | $8,075,123FY2024 |
| Roger Baldwin Foundation of Aclu IncChicago | Form 990 | $7,993,015FY2025 |
| Nicasa NFPRound Lake | Form 990 | $7,979,643FY2025 |
| Human Resources Center of Edgar & Clark CountiesMarshall | Form 990 | $7,844,534FY2025 |
| Champaign County YMCA Dba Stephens Family YMCAChampaign | Form 990 | $7,806,380FY2025 |
| Friends of the Historic Genesee TheatreWaukegan | Form 990 | $7,772,671FY2025 |
| East Central IL Community Action AgencyDanville | Form 990 | $7,706,680FY2025 |
| Galesburg Hospitals Ambulance ServiceGalesburg | Form 990 | $7,563,780FY2025 |
| Illinois Public Health AssociationSpringfield | Form 990 | $7,472,617FY2025 |
| American Brain Tumor AssociationChicago | Form 990 | $7,403,007FY2025 |
| Henry & Jane Vonderlieth Living Center IncMount Pulaski | Form 990 | $7,345,464FY2024 |
| Dermatology FoundationSkokie | Form 990 | $7,193,686FY2024 |
| City Colleges of Chicago FoundationChicago | Form 990 | $7,177,363FY2025 |
| Restoration Ministries IncHarvey | Form 990 | $7,175,842FY2025 |
| Area Agency on Aging for Lincolnland IncSpringfield | Form 990 | $7,164,300FY2025 |
| Young Mens Christian Assn NormalBloomington | Form 990 | $7,145,391FY2025 |