| Art Institute of ChicagoChicago | Form 990 | $464,393,130FY2025 |
| American College of SurgeonsChicago | Form 990 | $177,470,920FY2025 |
| Evans Scholars FoundationGlenview | Form 990 | $117,552,012FY2025 |
| Accreditation Council for Graduate Medical EducationChicago | Form 990 | $88,540,135FY2024 |
| Chicago Cook Workforce PartnershipChicago | Form 990 | $77,702,139FY2025 |
| Northern Illinois University FoundationDeKalb | Form 990 | $60,306,566FY2025 |
| National Merit Scholarship CorporationEvanston | Form 990 | $59,091,988FY2025 |
| Big Shoulders FundChicago | Form 990 | $53,155,887FY2025 |
| After School Matters IncChicago | Form 990 | $48,377,490FY2025 |
| Youth GuidanceChicago | Form 990 | $44,260,936FY2025 |
| American Library AssociationChicago | Form 990 | $40,436,015FY2025 |
| Hoyleton Youth and Family ServicesHoyleton | Form 990 | $32,244,212FY2025 |
| Emergency Nurses AssociationSchaumburg | Form 990 | $30,312,609FY2024 |
| Illinois Masonic Charities FundSpringfield | Form 990 | $28,654,557FY2025 |
| Pacific Oaks Education CorporationChicago | Form 990 | $28,364,886FY2025 |
| National Taiwan University Academic Development Foundation IncWillowbrook | Form 990 | $27,479,363FY2024 |
| Ui LabsChicago | Form 990 | $25,970,793FY2024 |
| University of Chicago Charter School CorporationChicago | Form 990 | $24,863,249FY2025 |
| Kleo Community Family Life CenterChicago | Form 990 | $24,721,398FY2025 |
| Leading Educators IncChicago | Form 990 | $22,369,384FY2025 |
| Action for Healthy Kids IncChicago | Form 990 | $21,027,510FY2025 |
| Foundation of the American College of Healthcare ExecutivesChicago | Form 990 | $19,834,816FY2024 |
| Cleveland Avenue Foundation for Education GroupChicago | Form 990 | $19,646,175FY2024 |
| Higher Learning CommissionChicago | Form 990 | $17,507,855FY2025 |
| Chicago Bar FoundationChicago | Form 990 | $15,447,025FY2025 |
| Childrens First Fund the Chicago Public School FoundationChicago | Form 990 | $15,132,032FY2025 |
| Sigma Chi FoundationEvanston | Form 990 | $14,971,831FY2025 |
| The Center Resources for Teaching and LearningArlington Heights | Form 990 | $14,749,005FY2025 |
| Eastern Illinois University FoundationCharleston | Form 990 | $14,527,380FY2025 |
| Community Educaton Network It Takes a Village Family of SchooChicago | Form 990 | $14,016,686FY2025 |
| Council of Medical Specialty SocietiesSchaumburg | Form 990 | $13,836,018FY2024 |
| Cristo Rey NetworkChicago | Form 990 | $13,819,943FY2025 |
| Western Illinois University FoundationMacomb | Form 990 | $13,187,852FY2025 |
| Riverbend Head Start Delegate IncAlton | Form 990 | $12,841,738FY2024 |
| Rockford Rescue Mission MinistriesRockford | Form 990 | $12,151,547FY2025 |
| National Center for Teacher Residencies IncChicago | Form 990 | $12,035,693FY2025 |
| Community Action Partnership of Lake CountyWaukegan | Form 990 | $11,694,088FY2024 |
| The Academy GroupChicago | Form 990 | $11,457,008FY2025 |
| Evanston Township High School District 202 Educ FoundationEvanston | Form 990 | $11,425,075FY2025 |
| Accreditation Council for Continuing Medical EducationChicago | Form 990 | $11,004,312FY2025 |
| American College of Foot and Ankle SurgeonsChicago | Form 990 | $10,430,974FY2024 |
| Primo Center for Women and ChildrenChicago | Form 990 | $10,357,922FY2025 |
| Glenwood AcademyGlenwood | Form 990 | $10,048,799FY2025 |
| Newberry LibraryChicago | Form 990 | $9,913,275FY2025 |
| Academy for Urban School LeadershipChicago | Form 990 | $9,688,015FY2025 |
| Illinois Association of Free and Charitable ClinicsLa Grange | Form 990 | $9,285,139FY2025 |
| Holy Family MinistriesWestchester | Form 990 | $9,063,972FY2025 |
| Alpha Kappa Alpha Educational Advancement Foundation IncChicago | Form 990 | $8,773,382FY2025 |
| One Million DegreesChicago | Form 990 | $8,447,741FY2025 |
| Rochelle Zell Jewish High SchoolDeerfield | Form 990 | $8,250,632FY2025 |